Annual reports in medicinal chemistry. / Volume 9 by Maxwell Gordon; et al

By Maxwell Gordon; et al

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2, cannabigerol cannabichromene (3, and cannabicyclol ( 4 A d e s c r i p t i o n o f the a b s o l u f t c o n f i g u r a t i o n 3111 o f both c h i r a l c e n t e r s (C-3 and C-4) i n 1 -THC a s & was also presented. $&fls on t h e t o t 3 1 syntheses o f ( 5 ) cannabidiol (+J d 5 - T H C , (-) d l - T H C , (-) -THC, as well a s t h e racemic and ( + ) l n o d i f i c a t i o n s of t h e l a t t e r two THC'S, were - 4. (z), - (z), -3 p 4 -5 -6 published. 20-1 Other cannabinoid r e p a r a t i o n s i n v o l v i n g t h e condensation of terpenoid moieties were a l s o described.

Pharmacol. E x p . , 179. 236 (1971). B. Leonard, Psychopharmacologia, 2 33 (1973). A. Taunton-Rigby, S. Sher, and P. Kelley, Science, 181. 165 (1973). A. C a s t r o , 2. C r e t t i e , F. Bartos, and D. Eartos, Res. Commun. Cheai. Tathol. P h a m c o l . , 5 879 (1973). S. S c h n o l l , W. Vogel, C. O d s t r c h e l , Fed. , Fed. Amer. SOC. Exp. , 2852 Abs. (1973). 8. VanVunakis, J. Farrow, H. C j i k a and L. Levine, Proc. Nat. Acad. , 3 1483 (1971). I. Diab, D. Freedmn, and L. Roth, Science, 173.

194. 195. 196. 197. 198. 199. 200. Sect. I - CNS Agents Gordon, Ed. H. Perez-Reyes, M. T i m n s , H. Lipton, K. Davis, and H. Wall, S c i e n c e , 127, 633 (1972). H. C h r i s t e n s e n , R. F r e u d c n t h s l , J. Gidley, R. Rosrnfeld, C. Boe pli, L. T e s t i n o , D. Brine, C. P i t t , a n d M. iia11, Science, 172, 165 (1971). E. G i l l , C. Jones, and D. Lawrence, fllochern. P h a m c o l . , 22, 175 (1973). L. Lemberger, R. % r t z , B. Rodds, R. Forney, and H. Rowe, J. Clin. I n v e s t .

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