Amyotrophic Lateral Sclerosis (Neurological Disease and by Hiroshi Mitsumoto, Serge Przedborski, Paul H. Gordon

By Hiroshi Mitsumoto, Serge Przedborski, Paul H. Gordon

With state of the art contributions from across the world famous specialists and box pioneers, Amyotrophic Lateral Sclerosis is the definitive advisor to the topic. Formatted in an simply obtainable demeanour, with summaries of key issues on the finish of every bankruptcy, this consultant covers the entire crucial info clinicians require for day-by-day perform, in addition to supplying a reader-friendly method of each point of ALS with special sections at the scientific positive factors of affliction, translational study, sufferer care and administration, and rising cures.

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Amyotrophic Lateral Sclerosis (Neurological Disease and Therapy, 78)

With state-of-the-art contributions from the world over well-known specialists and box pioneers, Amyotrophic Lateral Sclerosis is the definitive consultant to the topic. Formatted in an simply available demeanour, with summaries of key issues on the finish of every bankruptcy, this advisor covers the entire crucial info clinicians require for day-by-day perform, in addition to supplying a reader-friendly method of each element of ALS with specified sections at the medical beneficial properties of affliction, translational study, sufferer care and administration, and rising treatments.

Extra info for Amyotrophic Lateral Sclerosis (Neurological Disease and Therapy, 78)

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Lambert outlined features, since referred to as the ‘‘Lambert criteria,’’ that he considered supportive of the diagnosis of ALS. He was careful to point out that the EMG findings in ALS are not pathognomonical, and also emphasized the importance of fasciculation potentials, which have been given less status in later diagnostic criteria (93). His reports on the electrophysiology of ALS are still considered unmatched for their broad description and deep insight (94). He was the president of the American Association of Electromyography and Electrodiagnosis in 1956, and was awarded its lifetime achievement award.

A. Thomas M. A. Wendy Johnston Neurology, University of Alberta, Alberta, Canada Jean-Pierre Julien Department of Anatomy and Physiology, Research Centre of CHUQ, Quebec City, Quebec, Canada Edward J. A. A. , and Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Fukuoka, Japan Jiming Kong Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada xxiv Contributors Lisa S. A. A. K. A. Lan Chi T. A. A. Jesse McLean Department of Cell Biology, Robarts Research Institute, London, Ontario, Canada Vincent Meininger France Fe´de´ration de Neurolgie Mazarin, Hoˆpital Salpe´trie`re, Paris, Robert G.

10 Gordon Lou was physically active and durable, as were other athletes who developed ALS. This has led to the hypothesis that athleticism may be a risk factor for ALS. Over the course of his consecutive game streak, Gehrig suffered a broken thumb, a broken toe, and back spasms. X-rays taken during his career showed 17 healed fractures in all (69). Lou, typical of those with ALS, was also a quiet and noble person. He handled his illness the same way he conducted himself in health, seeing himself ‘‘not a mere victim of a form of paralysis but a symbol of hope for thousands of sufferers of the same disorder’’ (70).

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